Mesothelioma- Pathophysiology, Asbsetos, Immunosuppressive Properties

Author: Robert Edwards




Pathophysiology, Asbestos,Immunosupressive Properties

Asbestos fibres have been indicated to alter the function and secretory properties of macrophages, which ultimately creates conditions that favour mesothelioma developmeny. Following asbestos phagocytosis, macrophages generate increased amounts of hydroxyl radicals. These are normal by-products of cellular anaerobic metabolism. However, these free radicals are also known clastogenic and membrane-active agents thought to encourage asbestos carcinogenicity. These oxidants participate in the oncogenic process by directly and indirectly interacting with DNA which consequently, modifies membrane-associated cellular events, including oncogene activation and perturbation of cellular antioxidant defences.

Asbestos also may possess immunosuppressive properties. For example, chrysotile fibres have indicated to depress the in vitro proliferation of phytohemagglutinin-stimulated peripheral blood lymphocytes, suppress natural killer cell lysis and significantly reduce lymphokine-activated killer cell viability and recovery. Furthermore, genetic alterations in asbestos-activated macrophages may end up in the release of potent mesothelial cell mitogens such as platelet-derived growth factor (PDGF) and transforming growth factor-β (TGF-β). This in turn, may bring about the chronic stimulation and proliferation of mesothelial cells after injury by asbestos which is then classified as advanced mesothelioma.


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  • Mesothelioma - Pathophysiology and Asbestos
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